The “Layout” menu's entries are self-explaining or discussed in detail in dedicated chapters.
Save Layout, Load Layout, Apply Layout
Learn how to customize RealFlow's GUI under → "User Interface".
Clean Layout
Maximize the viewport by removing all panels. To switch back to the default or any other saved layout, go to Apply Layout.
Clear Messages
Clean RealFlow's "Messages" window.
Single View, Quad View, etc.
Detailed explanations of RealFlow's layout panels can be found in the chapters of the → "GUI" reference.